FDA Resources. Arms and Interventions. Outcome Measures. Primary Outcome Measures : The proportion of subjects who are successfully stepped-down to single-dose PPI therapy, defined as having no recurrence of heartburn or acid regurgitation 3 months after PPI step-down. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. Layout table for additonal information ClinicalTrials. Reflux GERD. Consult your healthcare provider for a full list of adverse effects. Because Nexium and Prilosec are similar drugs with similar structures, they have similar drug interactions.
PPIs should not be taken with antiretrovirals. Nexium or Prilosec could decrease levels of atazanavir or nelfinavir, so the antiretroviral would not properly, and the interaction could even cause drug resistance. On the other hand, taking saquinavir with a PPI has the opposite effect, increasing levels of saquinavir, which could lead to toxicity. Combining Nexium or Prilosec with digoxin can increase levels of digoxin and lead to toxicity. Taking Nexium or Prilosec with warfarin can lead to increased levels of warfarin, which could cause bleeding or even death.
Nexium or Prilosec can interact with Plavix clopidogrel , diazepam , cilostazol , and other drugs. This is not a complete list of drug interactions. Consult your healthcare provider for a full list of drug interactions. Nexium, or esomeprazole, is a proton pump inhibitor PPI used to treat symptoms of acid reflux and other gastrointestinal GI conditions.
Nexium and Prilosec are in the drug class called proton pump inhibitors and are very similar. In fact, they are chemical isomers of each other. Other drugs in the PPI category you may have heard of include Aciphex rabeprazole , Protonix pantoprazole , and Prevacid lansoprazole.
There are some studies see above that suggest Nexium may be more effective and work faster than Prilosec and other PPIs. However, both drugs remain very popular and are well-tolerated. There is not enough information to generally say if you can take Nexium or Prilosec while pregnant. They cited concerns such as:. The authors analyzed 41 studies on the effectiveness of PPIs.
Until March , Nexium was available only by prescription and at a significantly higher price. However, generic omeprazole may be less expensive than Prilosec OTC. Work with your doctor or pharmacist to decide which PPI is best for you. In addition to cost, consider things like:. A link to possible dementia risk was reported in , but a larger confirmatory study in determined that there was no increased risk of dementia from using PPIs.
Many people experience excess acid production when they stop using PPIs. At the end of the recommended treatment duration, you should taper off of the medication gradually.
Work with your doctor to do so. Before taking either medication, talk to your doctor to learn about the risk factors and drug interactions associated with them. Always tell your doctor about all the drugs, herbs, and vitamins you take.
Prilosec and Nexium can interact with other medications you might be taking. The U. Food and Drug Administration FDA has issued a warning that the drug in Prilosec reduces the effectiveness of the blood thinner clopidogrel Plavix. Other drugs can interact with Nexium or Prilosec, but may still be taken with either drug. Tell your doctor if you take any of these drugs so they can evaluate your risk:. Lifestyle changes should be your first steps in controlling GERD and heartburn.
You may want to try:. It comes from acid backing up from your stomach to your throat. You may have seen ads for heartburn drugs, such as Nexium, Prilosec or Prevacid. These drugs are called PPIs proton pump inhibitors.
They keep the stomach from making too much acid. They have been shown to heal irritation of the tube between the throat and the stomach the esophagus. You can get relief from a less powerful drug. And when you do need a PPI, you should take the lowest dose for as short a time as possible.
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